本庶佑 高等研究院副院長・特別教授のノーベル賞受賞関連論文リンク集を公開しました(2018年10月3日公開)
投稿日 2018-12-11 | カテゴリ： 図書館機構2018年10月1日本庶佑 高等研究院副院長・特別教授のノーベル生理学・医学賞受賞が決定しました。
- 本庶佑高等研究院副院長・特別教授がノーベル生理学・医学賞を受賞（2018年10月1日） （京都大学ニュース記事）
- 本庶佑 高等研究院副院長・特別教授記者会見 （京都大学ニュース記事）
- The 2018 Nobel Prize in Physiology or Medicine - Press Release （The Official Web Site of the Nobel Prize）
■ Key publication
（全てフリーで閲覧可）
- Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Y. Ishida, Y. Agata, K. Shibahara, T. Honjo.
EMBO Journal, 11, 3887-3895 (1992).
DOI: 10.1002/j.1460-2075.1992.tb05481.x
本文（出版社サイトで見る）: https://onlinelibrary.wiley.com/doi/abs/10.1002/j.1460-2075.1992.tb05481.x
本文（PMCサイトで見る）: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556898/ - Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor.
Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T.
Immunity, 11, 141-151 (1999).
DOI: 10.1016/S1074-7613(00)80089-8
本文（出版社サイトで見る）: https://www.sciencedirect.com/science/article/pii/S1074761300800898?via%3Dihub
本文（PMCサイトで見る）: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556898/ - Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitsz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T.
Journal of Experimental Medicine, 192, 1027-1034 (2000).
DOI: 10.1084/jem.192.7.1027
本文（出版社サイトで見る）: http://jem.rupress.org/content/192/7/1027
本文（PMCサイトで見る）: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/ - PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
Iwai, Y., Terawaki, S., & Honjo, T.
International Immunology, 17(2), 133–144 (2005).
DOI: 10.1093/intimm/dxh194
本文（出版社サイトで見る）: https://academic.oup.com/intimm/article/17/2/133/843513
■ 本庶佑特別教授 主要論文リスト
参照：本庶佑 履歴・代表論文（京都大学大学院医学研究科免疫ゲノム医学内サイト）
※論文情報については今後も更新します。
※本文閲覧には、別途購読契約が必要な場合があります。
◆免疫抑制受容体PD-1に関する研究
- Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
Y. Ishida, Y. Agata, K. Shibahara, T. Honjo.
EMBO J. 11 3887-3895 (1992).
DOI: 10.1002/j.1460-2075.1992.tb05481.x - Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor.
Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T.
Immunity 11 141-151 (1999).
DOI: 10.1016/S1074-7613(00)80089-8 - Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitsz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T.
J. Exp. Med. 192 1027-1034 (2000).
DOI: 10.1084/jem.192.7.1027 - PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
Latchman, Y., Wood, C., Chernova, T., Borde, M., Chernova, I., Iwai, Y., Malenkovich, N., Long, A., Bourque, K., Boussiotis, V., Nishimura, H., Honjo, T., Sharpe, A. and Freeman, G.
Nature Immunol. 2 261-268 (2001)
DOI: 10.1038/85330
Share this article: https://rdcu.be/8mps - Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice.
Nishimura, H., Tanaka, Y., Okazaki, T., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Hiai, H., Minato, N. and Honjo, T.
Science 291 319-322 (2001)
DOI: 10.1126/science.291.5502.319 - Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Iwai, Y., shida, M., Tanaka, Y., Okazaki, T., Honjo, T. and Minato, N.
Proc. Natl. Acad. Sci. USA 99 12293-12297 (2002)
DOI: 10.1073/pnas.192461099 - Autoantibodies against cardiac troponin I are responsible for the dilated cardiomyopathy in PD-1 deficient mice.
Okazaki, T., Tanaka, Y., Nishio, R., Mitsuie, T., Mizoguchi, A., Jian, W., Ishida, M., Matsumori, A., Minato,. N. and Honjo, T.
Nature Medicine 9 1477-1483 (2003)
DOI: 10.1038/nm955
Share this article: https://rdcu.be/8mqV - Rejuvenating exhausted T cells during chronic viral infection.
Okazaki T, Honjo T.
Cell. 124(3):459-61 (2006)
DOI: 10.1016/j.cell.2006.01.022 - Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S.
PNAS. 104(9):3360-5 (2007)
DOI: 10.1073/pnas.0611533104 - TRIM28 prevents autoinflammatory T cell development in vivo.
Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T.
Nat Immunol. 13(6):596-603 (2012)
DOI: 10.1038/ni.2293
Share this article: https://rdcu.be/8mrs - A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T.
Nat Immunol. 14(12):1212-8 Review (2013)
DOI: 10.1038/ni.2762
Share this article: https://rdcu.be/8mrJ
KURENAI: http://hdl.handle.net/2433/193052
◆学位論文
- ADENOSINE DIPHOSPHATE RIBOSYLATION OF AMINOACYL TRANSFERASE II AND INHIBITION OF PROTEIN SYNTHESIS BY DIPHTHERIA TOXIN.
（アミノアシルトランスフェラーゼIIのADPリボシル化とジフテリア毒素による蛋白質合成の阻害）
Honjo, Tasuku (本庶, 佑)
京都大学 医学博士 医博第463号
授与年月日: 1975年1月23日
要旨: KURENAI: http://hdl.handle.net/2433/220563
◆京都大学学術情報リポジトリKURENAI掲載論文（上記以外）
- AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita, and Tasuku Honjo.
PNAS, 106 (52), 22375-22380 (2009).
DOI: 10.1073/pnas.0911879106
KURENAI: http://hdl.handle.net/2433/88967
京大プレスリリース: AIDによるクラススイッチの際DNA切断を起こすのはトポイソメラーゼ1であることを発見. （2009年12月8日） - B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.
Thinh Huy Tran, Mikiyo Nakata, Keiichiro Suzuki, Nasim A Begum, Reiko Shinkura, Sidonia Fagarasan, Tasuku Honjo & Hitoshi Nagaoka.
Nature Immunology, 11, 148–154 (2010)
DOI: 10.1038/ni.1829
KURENAI: http://hdl.handle.net/2433/88755
京大プレスリリース: ゲノムに抗体の記憶を刻むAID蛋白質遺伝子（Aicda）の発現制御機構－何故非Bリンパ球にAIDが発現し、癌化が起こり得るのか－を解明しました。（2009年12月7日） - Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
Andre Stanlie, Masatoshi Aida, Masamichi Muramatsu, Tasuku Honjo, and Nasim A. Begum.
PNAS, 107 (51) 22190-22195 (2010)
DOI: 10.1073/pnas.1016923108
KURENAI: http://hdl.handle.net/2433/141990 - Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Il-mi Okazaki, Katsuya Okawa, Maki Kobayashi, Kiyotsugu Yoshikawa, Shimpei Kawamoto, Hitoshi Nagaoka, Reiko Shinkura, Yoko Kitawaki, Hisaaki Taniguchi, Tohru Natsume, Shun-Ichiro Iemura, and Tasuku Honjo.
PNAS, 2011 108 (19) 7920-7925 (2011)
DOI: 10.1073/pnas.1104423108
KURENAI: http://hdl.handle.net/2433/141951 - Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
Maki Kobayashi, Zahra Sabouri, Somayeh Sabouri, Yoko Kitawaki, Yves Pommier, Takaya Abe, Hiroshi Kiyonari, and Tasuku Honjo.
PNAS, 2011 108 (48) 19305-19310 (2011)
DOI: 10.1073/pnas.1114522108
KURENAI: http://hdl.handle.net/2433/152359 - Activation-Induced Cytidine Deaminase Expression in CD4(+)T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.
Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo , Hitoshi Nagaoka.
PLoS ONE 6(12): e29141.
DOI: 10.1371/journal.pone.0029141
KURENAI: http://hdl.handle.net/2433/152386 - Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
Lucia Kato, Nasim A. Begum, A. Maxwell Burroughs, Tomomitsu Doi, Jun Kawai, Carsten O. Daub, Takahisa Kawaguchi, Fumihiko Matsuda, Yoshihide Hayashizaki, and Tasuku Honjo.
PNAS,109 (7) 2479-2484 (2012)
DOI: 10.1073/pnas.1120791109
KURENAI: http://hdl.handle.net/2433/154776 - RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.
Guoxin Liang, Kouichi Kitamura, Zhe Wang, Guangyan Liu, Sajeda Chowdhury, Weixin Fu, Miki Koura, Kousho Wakae, Tasuku Honjo, and Masamichi Muramatsu
PNAS, 110 (6) 2246-2251 (2013)
DOI: 10.1073/pnas.1221921110
KURENAI: http://hdl.handle.net/2433/171383 - Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.
Yuxiang Rui, Tasuku Honjo, and Shunsuke Chikuma
PNAS, 110 (40) 16073-16078 (2013)
DOI: 10.1073/pnas.1315828110
KURENAI: http://hdl.handle.net/2433/178757
京大プレスリリース: 免疫のブレーキPD-1が、自然免疫反応の調節によって免疫難病の発症を抑制することを解明. （2013年9月17日） - C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.
Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, and Tasuku Honjo.
PNAS, 111 (6) 2253-2258 (2014)
DOI: 10.1073/pnas.1324057111
KURENAI: http://hdl.handle.net/2433/183988 - Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi & Tasuku Honjo.
Nature Communications, 7: 10549 (2016)
DOI: 10.1038/ncomms10549
KURENAI: http://hdl.handle.net/2433/210233 - Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Baihao Zhang, Shunsuke Chikuma, Shohei Hori, Sidonia Fagarasan, and Tasuku Honjo
PNAS, 113 (30) 8490-8495 (2016)
DOI: 10.1073/pnas.1608873113
KURENAI: http://hdl.handle.net/2433/216040
京大プレスリリース: 免疫のブレーキPD-1は、制御性T細胞との役割分担によって自己免疫性膵炎を抑制する. （2016年7月20日） - Cancer immunotherapies targeting the PD-1 signaling pathway.
Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo.
Journal of Biomedical Science, 24:26 (2017)
DOI: 10.1186/s12929-017-0329-9
KURENAI: http://hdl.handle.net/2433/225265
◆和雑誌掲載論文
本庶佑京都大学名誉教授の医中誌収録文献 （医学中央雑誌刊行会）
（附属図書館学術支援掛）
