京都大学図書館機構

Shimon Sakaguchi, T Takahashi , Y Nishizuka.
Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer.
Journal of Experimental Medicine, 156 (1998), 1565–1576.
掲載誌刊行元で見る：https://doi.org/10.1084/jem.156.6.1565
PubMed Centralで見る：https://pmc.ncbi.nlm.nih.gov/articles/PMC2186857/（フリーアクセス）

Shimon Sakaguchi, Noriko Sakaguchi, Masanao Asano, Misako Itoh, Masaaki Toda.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
The Journal of Immunology, 155 (1995), 1151–1164.
掲載誌刊行元で見る：https://academic.oup.com/jimmunol/article/155/3/1151/8068613（フリーアクセス）

Kelvin Y. Chen, Tatsuya Kibayashi, Ambre Giguelay, Mayu Hata, Shunsuke Nakajima, Norihisa Mikami, Yusuke Takeshima, Kenji Ichiyama, Ryusuke Omiya, Leif S. Ludwig, Kunihiro Hattori, Shimon Sakaguchi.
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3.
Nature, 642 (2025), 191–200.
掲載誌刊行元で見る：https://doi.org/10.1038/s41586-025-08795-5

Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, Shimon Sakaguchi.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Proceedings of the National Academy of Sciences (PNAS), 119 (2022), e2114282119.
掲載誌刊行元で見る：https://doi.org/10.1073/pnas.2114282119（フリーアクセス）

Ryoji Kawakami, Yohko Kitagawa, Kelvin Y. Chen, Masaya Arai, Daiya Ohara, Yamami Nakamura, Keiko Yasuda, Motonao Osaki, Norihisa Mikami, Caleb A. Lareau, Hitomi Watanabe, Gen Kondoh, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi.
Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.
Immunity, 54 (2021), 947–961 E8.
掲載誌刊行元で見る：https://doi.org/10.1016/j.immuni.2021.04.005（フリーアクセス）

Shohei Hori, Takashi Nomura, Shimon Sakaguchi.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
Science, 299 (2003), 1057–1061.
掲載誌刊行元で見る：https://doi.org/10.1126/science.1079490

Shimon Sakaguchi.
Regulatory T Cells: Key Controllers of Immunologic Self-Tolerance.
Cell, 101 (2000), 455–458.
掲載誌刊行元で見る：https://doi.org/10.1016/s0092-8674(00)80856-9（フリーアクセス）

Takeshi Takahashi, Tomoyuki Tagami, Sayuri Yamazaki, Toshimitsu Uede, Jun Shimizu, Noriko Sakaguchi, Tak W. Mak, Shimon Sakaguchi.
Immunologic Self-Tolerance Maintained by Cd25⁺Cd4⁺Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4.
Journal of Experimental Medicine, 192 (2000), 303–310.
掲載誌刊行元で見る：https://doi.org/10.1084/jem.192.2.303
PubMed Centralで見る：https://pmc.ncbi.nlm.nih.gov/articles/PMC2193248/（フリーアクセス）

Misako Itoh, Takeshi Takahashi, Noriko Sakaguchi, Yuhshi Kuniyasu, Jun Shimizu, Fujio Otsuka, Shimon Sakaguchi.
Thymus and Autoimmunity: Production of CD25⁺CD4⁺ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance.
The Journal of Immunology, 162 (1999), 5317–5326.
掲載誌刊行元で見る：https://doi.org/10.4049/jimmunol.162.9.5317（フリーアクセス）

Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi.
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance.
Journal of Experimental Medicine, 223 (2026), e20251635.

Nathan D. Pennock, Yamin Qian, Kazumi Ishihara, Yamami Nakamura, Eric Cross, Shimon Sakaguchi, Jason T. White.
Thymically imprinted heterogeneity results in differential Treg induction and stability of effector identity.
Cell Reports, 44 (2025), 115791.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James B. Wing.
Single cell suppression profiling of human regulatory T cells.
Nature Communications, 16 (2025), 1325.

Yoshiaki Yasumizu, Masaki Hagiwara, Yuto Umezu, Hiroaki Fuji, Keiko Iwaisako, Masataka Asagiri, Shinji Uemoto, Yamami Nakamura, Sophia Thul, Azumi Ueyama, Kazunori Yokoi, Atsushi Tanemura, Yohei Nose, Takuro Saito, Hisashi Wada, Mamoru Kakuda, Masaharu Kohara, Satoshi Nojima, Eiichi Morii, Yuichiro Doki, Shimon Sakaguchi, Naganari Ohkura.
Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis.
NAR Cancer, 6 (2024), zcae022.

Shimon Sakaguchi, Ryoji Kawakami, Norihisa Mikami.
Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective.
Immunotherapy Advances, 3 (2023), ltad007.

Atsushi Tanaka, Shinji Maeda, Takashi Nomura, Mara Anais Llamas-Covarrubias, Satoshi Tanaka, Lin Jin, Ee Lyn Lim, Hiromasa Morikawa, Yohko Kitagawa, Shuji Akizuki, Yoshinaga Ito, Chihiro Fujimori, Keiji Hirota, Tosei Murase, Motomu Hashimoto, Junichi Higo, Rose Zamoyska, Ryuzo Ueda, Daron M. Standley, Noriko Sakaguchi, Shimon Sakaguchi.
Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.
Journal of Experimental Medicine, 220 (2023), e20220386.

Jonas Nørskov Søndergaard, Janyerkye Tulyeu, Ryuya Edahiro, Yuya Shirai, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Shimon Sakaguchi, Atsushi Kumanogoh, Yukinori Okada, James Badger Wing.
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients.
Proceedings of the National Academy of Sciences (PNAS), 120 (2023), e2217902120.

Dean Thumkeo, Siwakorn Punyawatthananukool, Somsak Prasongtanakij, Ryuma Matsuura, Kentaro Arima, Huan Nie, Rie Yamamoto, Naohiro Aoyama, Hisao Hamaguchi, Shingo Sugahara, Shinobu Takeda, Varodom Charoensawan, Atsushi Tanaka, Shimon Sakaguchi, Shuh Narumiya.
PGE₂-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.
Cell Reports, 39 (2022), 110914.

EP2/4阻害薬による抗腫瘍作用の機序解明―新しいがん免疫治療薬の開発に向けて― ［京都大学プレスリリース］

Masaya Arai, Aine Fukuda, Reo Morimoto, Yamami Nakamura, Zhaohong Ci, Shimon Sakaguchi.
Protocol to evaluate cell lineage stability of mouse natural and induced regulatory T cells using bisulfite sequencing.
STAR Protocols, 3 (2022), 101694.

Takashi Mikami, Itaru Kato, James Badger Wing, Hiroo Ueno, Keiji Tasaka, Kuniaki Tanaka, Hirohito Kubota, Satoshi Saida, Katsutsugu Umeda, Hidefumi Hiramatsu, Tomoya Isobe, Mitsuteru Hiwatari, Ai Okada, Kenichi Chiba, Yuichi Shiraishi, Hiroko Tanaka, Satoru Miyano, Yuki Arakawa, Koichi Oshima, Katsuyoshi Koh, Souichi Adachi, Keiko Iwaisako, Seishi Ogawa, Shimon Sakaguchi, Junko Takita.
Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia.
Cancer Science, 113 (2022), 41–52.

Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Noriko Sakaguchi, Shimon Sakaguchi, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota.
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.
Scientific Reports, 11 (2021), 18679.

Norihisa Mikami, Ryoji Kawakami, Kelvin Y. Chen, Atsushi Sugimoto, Naganari Ohkura, Shimon Sakaguchi.
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Proceedings of the National Academy of Sciences (PNAS), 117 (2020), 12258–12268.

Atsushi Tanaka, Hiroyoshi Nishikawa, Shinsuke Noguchi, Daisuke Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, Danbee Ha, Naoya Shigeta, Toshio Kitawaki, Yuka Maeda, Takuro Saito, Yoshinori Shinohara, Yoshihiro Kameoka, Keiko Iwaisako, Fumihiko Monma, Kohshi Ohishi, Julia Karbach, Elke Jäger, Kenichi Sawada, Naoyuki Katayama, Naoto Takahashi, Shimon Sakaguchi.
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Journal of Experimental Medicine, 217 (2020), e20191009.

Keiji Hirota, Motomu Hashimoto, Yoshinaga Ito, Mayumi Matsuura, Hiromu Ito, Masao Tanaka, Hitomi Watanabe, Gen Kondoh, Atsushi Tanaka, Keiko Yasuda, Manfred Kopf, Alexandre J. Potocnik, Brigitta Stockinger, Noriko Sakaguchi, Shimon Sakaguchi.
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity, 48 (2018), 1220–1232 E5.

自己免疫性関節炎の発症・慢性化に関わる新規細胞群と炎症ネットワークメカニズムの発見　［京都大学プレスリリース］

Garima Garg, Eirini Nikolouli, Matthias HardtkeWolenski, Aras Toker, Naganari Ohkura, Michael Beckstette, Takahisa Miyao, Robert Geffers, Stefan Floess, Norbert Gerdes, Esther Lutgens, Anke Osterloh, Shohei Hori, Shimon Sakaguchi, Elmar Jaeckel, Jochen Huehn.
Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.
Oncotarget, 8 (2017), 35542– 35557.

Takayoshi Morita, Yoshihito Shima, James Badger Wing, Shimon Sakaguchi, Atsushi Ogata, Atsushi Kumanogoh.
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis.
PLoS ONE, 11 (2016), e0162306.

Hiroko Fujii, Akiko Arakawa, Daisuke Utsumi, Shinji Sumiyoshi, Yosuke Yamamoto, Akihiko Kitoh, Masahiro Ono, Yumi Matsumura, Mayumi Kato, Keisuke Konishi, Takeo Shiga, Shigetoshi Sano, Shimon Sakaguchi, Aya Miyagawa-Hayashino, Kenzo Takahashi, Hiroshi Uezato, Yoshiki Miyachi, Miki Tanioka.
CD8⁺ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma.
International Journal of Cancer, 134 (2014), 2393–2402.

Ye Htun Oo, Shimon Sakaguchi.
Regulatory T-cell directed therapies in liver diseases.
Journal of Hepatology, 59 (2013), 1127–1134.

Yoshinaga Ito, Shimon Sakaguchi.
Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene.
Arthritis Research & Therapy, 14 (2012), O10.

Yorifumi Satou, Jun-ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L. Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka.
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo.
PLoS Pathogens, 7 (2011), e1001274.

Naganari Ohkura, Shimon Sakaguchi.
Regulatory T cells: roles of T cell receptor for their development and function.
Seminars in Immunopathology, 32 (2010), 95–106.

Motomu Hashimoto, Keiji Hirota, Hiroyuki Yoshitomi, Shinji Maeda, Shin Teradaira, Shuji Akizuki, Paz Prieto-Martin, Takashi Nomura, Noriko Sakaguchi, Jörg Köhl, Birgitta Heyman, Minoru Takahashi, Teizo Fujita, Tsuneyo Mimori, Shimon Sakaguchi.
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.
Journal of Experimental Medicine, 207 (2010), 1135–1143.

Toshiko Sakihama, Takato Sato, Hiroko Iwanari, Toshio Kitamura, Shimon Sakaguchi, Tatsuhiko Kodama, Takao Hamakubo.
A Simple Detection Method for Low-Affinity Membrane Protein Interactions by Baculoviral Display.
PLoS ONE, 3 (2008), e4024.