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Period : from 22:00 February 13 to 7:00 February 14, 2019

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(2018.12.13)
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938 new items have been released in Kyoto University Rare Materials Digital Archive: 477 writings by royalists from "Collage on Folding Screens, Meiji Restoration Collection", and 461 Korean rare books from "Kawai Collection" and others digitized in collaboration with Korea University.
As of December 12, 2018, Kyoto University Rare Materials Digital Archive has 1,047,928 images of 11,350 titles, surpassing the one million mark.

■Collage on Folding Screens (Meiji Restoration Collection) 477 titles
Viscount Yajiro Shinagawa, who had collected relics of late royalists during the Meiji Restoration and founded Sonjodo, organized letters, petitions, memorandums, paintings and poems by the royalists and posted them on folding screens in order to secure their long-term preservation. Presently there exist 23 folding screens among “Meiji Restoration Collection”: 21 consisting of six panels each and the rest, two panels each. The records of the writings in the digital archive include the images of the individual writings and the folding screens on which they are posted.

[caption id="" align="alignnone" width="603" class="right"] Collage on Folding Screen (No.757)[/caption]

[caption id="" align="alignnone" width="618" class="right"] Collage on Folding Screen (No.773)[/caption]

 

■Korean Rare Books (Kawai Collection and others) 461 titles
Kawai Collection consists of Korean rare manuscripts and books formerly held by Dr. Hirotami Kawai (1872-1918) who studied mainly history of Korea and its economy. Then Kyoto Imperial University (presently Kyoto University) bought the collection from his family in 1919 and has preserved it since then. The collection is indispensable in the research of Korean society, culture and especially finance, because it covers many fields such as official and private records, politics, economy, religion and customs. The items newly released this time are 461 titles of Korean rare books from Kawai Collection and others digitized under the collaborative project between Kyoto University Library, the Institute for Research in Humanities, Kyoto University and the Research Institute of Korean Studies, Korea University.

[caption id="" align="alignnone" width="298" class="right"] Kaisa zenzu (Kawai Collection)[/caption]

[caption id="" align="alignnone" width="734" class="right"] Myouhou rengekyou (Other Rare Materials)[/caption]

 

Solved! (12 Dec. 14:53)

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[Academic Support Division, Main Library]

Sorry, this entry is only available in 日本語.

The 2018 Nobel Prize in Physiology or Medicine has been awarded in part to Tasuku Honjo, distinguished professor and deputy director-general at the Kyoto University Institute for Advanced Study (KUIAS).

• 2018 Nobel Prize in Physiology or Medicine awarded to Distinguished Professor Tasuku Honjo (1 October 2018) (Kyoto University)
• Tasuku Honjo speaks at a press conference following Nobel announcement (1 October 2018) (Kyoto University)
• The 2018 Nobel Prize in Physiology or Medicine - Press Release （The Official Web Site of the Nobel Prize）

■ Key publication

（All Free）

• Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
  Y. Ishida, Y. Agata, K. Shibahara, T. Honjo.
  EMBO Journal, 11, 3887-3895 (1992).
  DOI: 10.1002/j.1460-2075.1992.tb05481.x
  Full Text (Publisher): https://onlinelibrary.wiley.com/doi/abs/10.1002/j.1460-2075.1992.tb05481.x
  Full Text (PMC site): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556898/
• Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor.
  Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T.
  Immunity, 11, 141-151 (1999).
  DOI: 10.1016/S1074-7613(00)80089-8
  Full Text (Publisher): https://www.sciencedirect.com/science/article/pii/S1074761300800898?via%3Dihub
  Full Text (PMC site): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556898/
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
  Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitsz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T.
  Journal of Experimental Medicine, 192, 1027-1034 (2000).
  DOI: 10.1084/jem.192.7.1027
  Full Text (Publisher):  http://jem.rupress.org/content/192/7/1027
  Full Text (PMC site): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/
• PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
  Iwai, Y., Terawaki, S., & Honjo, T.
  International Immunology, 17(2), 133–144 (2005).
  DOI: 10.1093/intimm/dxh194
  Full Text (Publisher): https://academic.oup.com/intimm/article/17/2/133/843513

■ The Selected List of Publications of Professor Tasuku Honjo

Reference: CV & Selected Publications (Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine)

  #We will continue to update this list.
  #A subscription may be required to access the full text in some cases.

◆Studies on Immuno-inhibotory receptor PD-1

• Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
  Y. Ishida, Y. Agata, K. Shibahara, T. Honjo.
  EMBO J. 11 3887-3895 (1992).
  DOI: 10.1002/j.1460-2075.1992.tb05481.x
• Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor.
  Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T.
  Immunity 11 141-151 (1999).
  DOI: 10.1016/S1074-7613(00)80089-8
• Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
  Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitsz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T.
  J. Exp. Med. 192 1027-1034 (2000).
  DOI: 10.1084/jem.192.7.1027
• PD-L2 is a second ligand for PD-1 and inhibits T cell activation.
  Latchman, Y., Wood, C., Chernova, T., Borde, M., Chernova, I., Iwai, Y., Malenkovich, N., Long, A., Bourque, K., Boussiotis, V., Nishimura, H., Honjo, T., Sharpe, A. and Freeman, G.
  Nature Immunol. 2 261-268 (2001)
  DOI: 10.1038/85330
  Share this article: https://rdcu.be/8mps
• Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice.
  Nishimura, H., Tanaka, Y., Okazaki, T., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Hiai, H., Minato, N. and Honjo, T.
  Science 291 319-322 (2001)
  DOI: 10.1126/science.291.5502.319
• Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
  Iwai, Y., shida, M., Tanaka, Y., Okazaki, T., Honjo, T. and Minato, N.
  Proc. Natl. Acad. Sci. USA 99 12293-12297 (2002)
  DOI: 10.1073/pnas.192461099
• Autoantibodies against cardiac troponin I are responsible for the dilated cardiomyopathy in PD-1 deficient mice.
  Okazaki, T., Tanaka, Y., Nishio, R., Mitsuie, T., Mizoguchi, A., Jian, W., Ishida, M., Matsumori, A., Minato,. N. and Honjo, T.
  Nature Medicine 9 1477-1483 (2003)
  DOI: 10.1038/nm955
  Share this article: https://rdcu.be/8mqV
• Rejuvenating exhausted T cells during chronic viral infection.
  Okazaki T, Honjo T.
  Cell. 124(3):459-61 (2006)
  DOI: 10.1016/j.cell.2006.01.022
• Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
  Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S.
  PNAS. 104(9):3360-5 (2007)
  DOI: 10.1073/pnas.0611533104
• TRIM28 prevents autoinflammatory T cell development in vivo.
  Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T.
  Nat Immunol. 13(6):596-603 (2012)
  DOI: 10.1038/ni.2293
  Share this article: https://rdcu.be/8mrs
• A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
  Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T.
  Nat Immunol. 14(12):1212-8 Review (2013)
  DOI: 10.1038/ni.2762
  Share this article: https://rdcu.be/8mrJ
  KURENAI: http://hdl.handle.net/2433/193052

◆Doctoral Dissertation

• ADENOSINE DIPHOSPHATE RIBOSYLATION OF AMINOACYL TRANSFERASE II AND INHIBITION OF PROTEIN SYNTHESIS BY DIPHTHERIA TOXIN.
  （アミノアシルトランスフェラーゼIIのADPリボシル化とジフテリア毒素による蛋白質合成の阻害）
  Honjo, Tasuku (本庶, 佑) 
  Kyoto University,  Ph.D. in Medical Science, 医博第463号
  Date Granted: January 23, 1975
  Abstract: KURENAI: http://hdl.handle.net/2433/220563

◆Articles in Kyoto University Research Information Repository KURENAI (other than that above)

• AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
  Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita, and Tasuku Honjo.
  PNAS, 106 (52), 22375-22380 (2009).
  DOI: 10.1073/pnas.0911879106
  KURENAI: http://hdl.handle.net/2433/88967
  Kyoto University Press Release : AIDによるクラススイッチの際DNA切断を起こすのはトポイソメラーゼ1であることを発見. （2009年12月8日）
• B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.
  Thinh Huy Tran, Mikiyo Nakata, Keiichiro Suzuki, Nasim A Begum, Reiko Shinkura, Sidonia Fagarasan, Tasuku Honjo & Hitoshi Nagaoka.
  Nature Immunology, 11, 148–154 (2010)
  DOI: 10.1038/ni.1829
  KURENAI: http://hdl.handle.net/2433/88755
  Kyoto University Press Release: ゲノムに抗体の記憶を刻むAID蛋白質遺伝子（Aicda）の発現制御機構－何故非Bリンパ球にAIDが発現し、癌化が起こり得るのか－を解明しました。（2009年12月7日）
• Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
  Andre Stanlie, Masatoshi Aida, Masamichi Muramatsu, Tasuku Honjo, and Nasim A. Begum.
  PNAS, 107 (51) 22190-22195 (2010)
  DOI: 10.1073/pnas.1016923108
  KURENAI: http://hdl.handle.net/2433/141990
• Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
  Il-mi Okazaki, Katsuya Okawa, Maki Kobayashi, Kiyotsugu Yoshikawa, Shimpei Kawamoto, Hitoshi Nagaoka, Reiko Shinkura, Yoko Kitawaki, Hisaaki Taniguchi, Tohru Natsume, Shun-Ichiro Iemura, and Tasuku Honjo.
  PNAS, 2011 108 (19) 7920-7925 (2011)
  DOI: 10.1073/pnas.1104423108
  KURENAI: http://hdl.handle.net/2433/141951
• Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
  Maki Kobayashi, Zahra Sabouri, Somayeh Sabouri, Yoko Kitawaki, Yves Pommier, Takaya Abe, Hiroshi Kiyonari, and Tasuku Honjo.
  PNAS, 2011 108 (48) 19305-19310 (2011)
  DOI: 10.1073/pnas.1114522108
  KURENAI: http://hdl.handle.net/2433/152359
• Activation-Induced Cytidine Deaminase Expression in CD4(+)T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.
  Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo , Hitoshi Nagaoka.
  PLoS ONE 6(12): e29141.
  DOI: 10.1371/journal.pone.0029141
  KURENAI: http://hdl.handle.net/2433/152386
• Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
  Lucia Kato, Nasim A. Begum, A. Maxwell Burroughs, Tomomitsu Doi, Jun Kawai, Carsten O. Daub, Takahisa Kawaguchi, Fumihiko Matsuda, Yoshihide Hayashizaki, and Tasuku Honjo.
  PNAS,109 (7) 2479-2484 (2012)
  DOI: 10.1073/pnas.1120791109
  KURENAI: http://hdl.handle.net/2433/154776
• RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.
  Guoxin Liang, Kouichi Kitamura, Zhe Wang, Guangyan Liu, Sajeda Chowdhury, Weixin Fu, Miki Koura, Kousho Wakae, Tasuku Honjo, and Masamichi Muramatsu
  PNAS, 110 (6) 2246-2251 (2013)
  DOI: 10.1073/pnas.1221921110
  KURENAI: http://hdl.handle.net/2433/171383
• Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.
  Yuxiang Rui, Tasuku Honjo, and Shunsuke Chikuma
  PNAS, 110 (40) 16073-16078 (2013)
  DOI: 10.1073/pnas.1315828110
  KURENAI: http://hdl.handle.net/2433/178757
  Kyoto University Press Release: 免疫のブレーキPD-1が、自然免疫反応の調節によって免疫難病の発症を抑制することを解明. （2013年9月17日）
• C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.
  Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, and Tasuku Honjo.
  PNAS, 111 (6) 2253-2258 (2014)
  DOI: 10.1073/pnas.1324057111
  KURENAI: http://hdl.handle.net/2433/183988
• Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
  Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi & Tasuku Honjo.
  Nature Communications, 7: 10549 (2016)
  DOI: 10.1038/ncomms10549
  KURENAI: http://hdl.handle.net/2433/210233
• Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
  Baihao Zhang, Shunsuke Chikuma, Shohei Hori, Sidonia Fagarasan, and Tasuku Honjo
  PNAS, 113 (30) 8490-8495 (2016)
  DOI: 10.1073/pnas.1608873113
  KURENAI: http://hdl.handle.net/2433/216040
  Kyoto University Press Release: 免疫のブレーキPD-1は、制御性T細胞との役割分担によって自己免疫性膵炎を抑制する. （2016年7月20日）
• Cancer immunotherapies targeting the PD-1 signaling pathway.
  Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo.
  Journal of Biomedical Science, 24:26 (2017)
  DOI: 10.1186/s12929-017-0329-9
  KURENAI: http://hdl.handle.net/2433/225265

◆Articles in Japanese

本庶佑京都大学名誉教授の医中誌収録文献  (Japan Medical Abstracts Society (JAMAS))   

 (Academic Support Section, Kyoto University Library)

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